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438192

Sigma-Aldrich

Anti-LRP, Light Chain Mouse mAb (5A6)

liquid, clone 5A6, Calbiochem®

Sinónimos:

Anti-Low Density Lipoprotein Receptor-Related Protein

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.43

origen biológico

mouse

Nivel de calidad

forma del anticuerpo

purified antibody

tipo de anticuerpo

primary antibodies

clon

5A6, monoclonal

formulario

liquid

no contiene

preservative

reactividad de especies

rabbit, mouse, human

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
avoid repeated freeze/thaw cycles

isotipo

IgG2

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... LRP1(4035)

Descripción general

Purified mouse monoclonal antibody. Recognizes the ~85 kDa LRP light chain protein under non-reducing conditions.
Recognizes the ~85 kDa LRP protein.
This Anti-LRP, Light Chain Mouse mAb (5A6) is validated for use in Frozen Sections, Immunoblotting, Paraffin Sections for the detection of LRP, Light Chain.

Inmunógeno

Human
purified, human placenta LRP

Aplicación

Frozen Sections (1-5 µg/ml)

Immunoblotting (1-5 µg/ml)

Paraffin Sections (1-5 µg/ml, see application references)

Envase

Please refer to vial label for lot-specific concentration.

Advertencia

Toxicity: Standard Handling (A)

Forma física

In 100 mM NaCl, 50 mM sodium phosphate, 1 mM EDTA, pH 6.6.

Reconstitución

Following initial thaw, aliquot and freeze (-20°C).

Otras notas

Mikhailenko, I., et al. 2001. J. Biol. Chem.276, 39484.
Rebeck, W.G., et al. 2001. Mol. Brain Res.87, 238.
Coukos, G., et al. 1994. Am. J. Pathol.144, 383.
Daugherty, A., and Rateri, D.L. 1994. Arterioscler Thromb.14, 2017.
Strickland, D.K., et al. 1990. J. Biol. Chem.265, 17401.
Variables associated with assay conditions will dictate the proper working dilution.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Junling Yang et al.
Journal of molecular neuroscience : MN, 49(2), 277-288 (2012-09-05)
We previously reported that anti-amyloid-beta (Aβ) single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an Alzheimer's disease (AD) mouse model without inducing inflammation. Here, we investigated the prophylactic effects and
Abhay P Sagare et al.
The Journal of biological chemistry, 288(21), 15154-15166 (2013-04-13)
Soluble low density lipoprotein receptor-related protein-1 (sLRP1) binds ~70% of amyloid β-peptide (Aβ) in human plasma. In Alzheimer disease (AD) and individuals with mild cognitive impairment converting to AD, plasma sLRP1 levels are reduced and sLRP1 is oxidized, which results
Robert D Bell et al.
Nature cell biology, 11(2), 143-153 (2008-12-23)
Amyloid beta-peptide (Abeta) deposition in cerebral vessels contributes to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in
Tomomi Kiyota et al.
Journal of neuroimmunology, 319, 80-92 (2018-03-27)
We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ, and rescued cognitive impairment with increased hippocampal
Arne Herring et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(1), 117-128 (2011-09-29)
Physical activity protects brain function in healthy individuals and those with Alzheimer's disease (AD). Evidence for beneficial effects of parental exercise on the health status of their progeny is sparse and limited to nondiseased individuals. Here, we questioned whether maternal

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