438075

Longdaysin

A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities with moderate selectivity over Cdk7 and Erk2.

• Sinónimos: Longdaysin, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine, Casein Kinase I Inhibitor VII, Casein Kinase I Inhibitor VII, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
• Fórmula empírica (notación de Hill): C₁₆H₁₆F₃N₅
• Número de CAS: 1353867-91-0
• Peso molecular: 335.33
• Número MDL: MFCD20527323
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥99% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 50 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities (IC₅₀ = 5.6 and 8.8 µM) with moderate selectivity over Cdk7 and Erk2 (IC₅₀ = 29 and 52 µM). Shown to block CKIα/δ-mediated phosphorylation of PER1, a clock protein, (IC₅₀ ~ 9 µM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~ 13 hrs at 10 µM) much more effectively than Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) and IC261 (Cat. No. 400090) and in larval zebra fish.

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful (C)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Hirota, T., et al. 2010. PLoS Biol.8, e1000559.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable