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351801

Glucose Transporter Inhibitor III, STF-31

Name: Glucose Transporter Inhibitor III, STF-31
Brand: MM
Price: 156 EUR

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

Sinónimos:

Glucose Transporter Inhibitor III, STF-31, STF-31

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A ustedes/SKU	Disponibilidad	Precio
10 mg	Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	156,00 €

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Fórmula empírica (notación de Hill):

C₂₃H₂₅N₃O₃S

Peso molecular:

423.53

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD04153828

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

156,00 €

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Propiedades

Quality Segment

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C

InChI key

NGQPRVWTFNBUHA-UHFFFAOYSA-N

Descripción

General description

A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Este artículo	407625	573127	557520
Sigma-Aldrich 351801 Glucose Transporter Inhibitor III, STF-31	Sigma-Aldrich 407625 STAT3 Inhibitor XVI	Sigma-Aldrich 573127 STAT3 Inhibitor XII, SPI	Sigma-Aldrich 557520 Ro-31-8220
form solid	form solid	form solid	form solid
assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 50 mg/mL	solubility DMSO: 50 mg/mL, light pink-purple	solubility water: 100 mg/mL, DMSO: 50 mg/mL	solubility water: 1 mg/mL, DMSO: 100 mg/mL

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c