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344930

Furin Inhibitor I

≥90% (HPLC), solid, furin inhibitor, Calbiochem®

Sinónimos:

Furin Inhibitor I, Decanoyl-RVKR-CMK

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A ustedes/SKUDisponibilidadPrecio
1 mg
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230,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C34H66ClN11O5
Peso molecular:
744.41
UNSPSC Code:
12352200
NACRES:
NA.28
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated

230,00 €

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Nombre del producto

Furin Inhibitor I, Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Quality Segment

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

off-white

solubility

methanol: 1 mg/mL, DMSO: soluble

shipped in

ambient

storage temp.

−20°C

General description

A peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
A peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Cell permeable: yes
Primary Target
viral glycoproteins

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Decanoyl-Arg-Val-Lys-Arg-CMK
Sugrue, R.J., et al. 2001. J. Gen. Virol.82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem.276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol.26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

219421

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form

solid

form

lyophilized

form

solid

form

solid

assay

≥90% (HPLC)

assay

≥95% (HPLC), ≥95% (TLC)

assay

≥90% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

methanol: 1 mg/mL, DMSO: soluble

solubility

DMSO: 5 mg/mL

solubility

DMSO: 30 mg/mL, ethanol: 30 mg/mL, methanol: soluble

solubility

DMSO: 20 mM

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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