264155

Caspase-3 Inhibitor II

≥90% (TLC), irreversible CPP-32/apopain inhibitor, solid

• Sinónimos: Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK
• Fórmula empírica (notación de Hill): C₃₀H₄₁FN₄O₁₂
• Número CAS: 210344-95-9
• Peso molecular: 668.66
• MDL number: MFCD23380217
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (TLC)
• Form: solid
• Storage condition: OK to freeze, desiccated

Propiedades

• Nombre del producto: Caspase-3 Inhibitor II, The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
• Quality Segment: 200
• assay: ≥90% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white to slightly brown
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC)CCC(=O)OC)C(C)C)CC(=O)OC
• InChI: 1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
• InChI key: GBJVAVGBSGRRKN-JYEBCORGSA-N

Descripción

General description

A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable