218759

Caspase-8 Inhibitor II

≥98% (HPLC), powder, Caspase-8 inhibitor, Calbiochem^®

• Sinónimos: Caspase-8 Inhibitor II, Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
• Fórmula empírica (notación de Hill): C₃₀H₄₃FN₄O₁₁
• Peso molecular: 654.68
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: powder
• Storage condition: OK to freeze, desiccated

Propiedades

• Nombre del producto: Caspase-8 Inhibitor II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
• Quality Segment: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white to yellow
• solubility: DMSO: 10 mM
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840 ) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.

Analysis Note

≥98% (HPLC)

Other Notes

Takizawa, T., et al. 1999. Microbiol. Immunol.43, 245.
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998. Science281, 1312.

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable