207001

Calcineurin Autoinhibitory Peptide, Cell-permeable

The Calcineurin Autoinhibitory Peptide, Cell-permeable controls the biological activity of Mn2+-stimulated calcineurin activity. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Calcineurin Autoinhibitory Peptide, Cell-permeable, 11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂
• Fórmula empírica (notación de Hill): C₁₃₇H₂₅₁N₇₁O₃₄S₂
• Peso molecular: 3501.04
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: lyophilized solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubilidad: water: 1 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A cell-permeable peptide that consists of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction doamin (11R) and acts as an inhibitor of CaN phosphatase activity. Reported to block CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Also reported to protect neuronal cells from glutamate-induced cell death.

A cell-permeable peptide that is composed of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction domain (11R) and acts as an inhibitor of CaN phosphatase activity. Blocks CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Protects neuronal cells from glutamate-induced cell death.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Blocks CaN-dependent NFAT nuclear translocation

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Secuencia

Ac-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂

Otras notas

Terada, H., et al. 2003. J. Neurochem.87, 1145.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable