204883

Complement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

• Código UNSPSC: 12352202
• NACRES: NA.25

Propiedades

• Nivel de calidad: 100
• Análisis: ≥90% (SDS-PAGE)
• formulario: liquid
• no contiene: preservative
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles
• impurezas: IgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin, trace
• Condiciones de envío: wet ice
• temp. de almacenamiento: −70°C

Descripción

Descripción general

Native, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.

Native, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.

Acciones bioquímicas o fisiológicas

≥80% of C1-esterase inhibitor will bind activated C1s.

Envase

Please refer to vial label for lot-specific concentration.

Advertencia

Toxicity: Standard Handling (A)

Forma física

In PBS, pH 7.4, sterile-filtered through a 0.22 µm filter.

Nota de preparación

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitución

Following initial thaw, aliquot and freeze (-70°C).

Otras notas

Bowen, B., et al. 2001. Clin. Immunol.98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.

Variables associated with assay conditions will dictate the proper working dilution.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable