203734-M

Brevetoxin PbTx-3, Ptychodiscus brevis

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida.

• Sinónimos: Brevetoxin PbTx-3, Ptychodiscus brevis, Pumiliotoxin, Dihydrobrevetoxin B
• Fórmula empírica (notación de Hill): C₅₀H₇₂O₁₄
• Número de CAS: 85079-48-7
• Peso molecular: 897.10
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: >95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• solubilidad: ethanol: 10 mg/mL; DMSO: 30 mg/mL; acetonitrile: 30 mg/mL; chloroform: 30 mg/mL; methanol: 30 mg/mL; water: sparingly soluble
• temp. de almacenamiento: −20°C
• InChI: 1S/C50H72O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,26,28-42,44-45,51-52H,1,11-15,17-24H2,2-8H3/b10-9-
• Clave InChI: BKMHDYJRAAJTAD-KTKRTIGZSA-N

Descripción

Descripción general

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.

Acciones bioquímicas o fisiológicas

Primary Target
Voltage-dependent Na+ channel activator

Advertencia

Toxicity: Highly Toxic (H)

Reconstitución

Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use PTFE or silicon pipette tips.

Otras notas

Baden, D.G., et al. 1994. Nat. Toxins2, 212.
Rein, K., et al. 1994. J. Org. Chem.59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res.14, 64.
Trainer, V.L. 1991. Mol. Pharmacol.40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol.103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series418, 166.
Baden, D.G., et al. 1988. Toxicon26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol.30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc.108, 514.
Baden, D.G., et al. 1982. Toxicon19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol.19, 345.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H300,H410
• Consejos de prudencia: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable