189404

Aurora Kinase Inhibitor II

The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Aurora Kinase Inhibitor II, 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
• Fórmula empírica (notación de Hill): C₂₃H₂₀N₄O₃
• Número de CAS: 331770-21-9
• Peso molecular: 400.43
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥90% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)
• Clave InChI: IMYVCWQAHSYYOO-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

A cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Aurora Kinase

Product competes with ATP.

Reversible: no

Target IC₅₀: 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett.16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem.5, 807.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable