16-256

Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor^™ 488

clone 1H6, Upstate^®, from mouse

• Sinónimos: 488-Alexa Fluor Antibody, Alexa Fluor 488 Detection, Clone 1H6 Anti-Phosphatidylserine
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: ALEXA FLUOR^™ 488
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 1H6, monoclonal
• reactividad de especies: vertebrates
• fabricante / nombre comercial: Upstate^®
• técnicas: flow cytometry: suitable
• isotipo: IgG
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: phosphorylation (pSer)

Descripción

Descripción general

Significance:
Anti-Phosphatidylserine may be used to detect translocation of the membrane phospholipid phosphatidylserine (PS) from the inner to the outer cell membrane leaflet; it provides an alternative to Annexin V for quantitation of apoptosis.

Phosphatidylserine, or PS, is a naturally occurring, phospholipid nutrient. PS is essential to the functioning of all the cells of the body, but is most concentrated in the brain. Its relative abundance in this organ reflects its proven involvement in an assortment of nerve cell functions, including nerve transmitter release and synaptic activity. Clinical studies have suggested that PS can support brain functions that tend to decline with age.

Especificidad

Recognizes phosphatidylserine (PS) in cell membranes.

Inmunógeno

Liposomes containing 70% phosphatidylserine and 30% phosphatidylglycerol.

Aplicación

Detect Phosphatidylserine using this Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor 488 validated for use in FC.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Calidad

Flow Cytometry: 0.2 μg of this antibody detected Phosphatidylserine in fixed Jurkat cells (see page 2).

Apoptosis Assay: Time course for induction of apoptosis in Jurkat cells by staurosporine, measured using either an Anti-Phosphatidylserine, clone 1H6, Alexa Fluor^™ 488 conjugate or an Annexin V FITC conjugate.

Forma física

Protein G Purified

Purified mouse monoclonal IgG in buffer containing PBS containing 1% BSA, 0.05% Tween, 0.05% sodium azide. Liquid at 4ºC.

Almacenamiento y estabilidad

Stable for 1 year at from date of receipt.

Nota de análisis

Control
Negative Control: Catalog # 16-240, Normal Mouse IgG, Alexa Fluor^™ 488-conjugate.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información legal

ALEXA FLUOR is a trademark of Life Technologies

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Alexa Fluor^™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable