119139

Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA

A highly selective agonist of adenosine A3 receptor (K_i = 330 pM)

• Sinónimos: Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA
• Fórmula empírica (notación de Hill): C₁₈H₁₈ClIN₆O₄
• Número de CAS: 163042-96-4
• Peso molecular: 544.73
• Número MDL: MFCD01861178
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 20 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1
• Clave InChI: IPSYPUKKXMNCNQ-PFHKOEEOSA-N

Descripción

Descripción general

A highly selective agonist of adenosine A3 receptor (K_i = 330 pM)

An adenosine analog that acts as a highly selective agonist of adenosine A₃ receptor (K_i = 330 pM, 820 nM, 470 nM for A₃, A₁ and A_2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Kim, H. O., et al. 1994. J Med Chem.37, 3614.
Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83.
Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable