07-276
Anti-PDGFRα Antibody
Upstate®, from rabbit
Sinónimos:
Anti-Anti-CD140A, Anti-Anti-PDGFR-2, Anti-Anti-PDGFR2
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25 μL
151,00 €
200 μL
433,00 €
151,00 €
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25 μL
151,00 €
200 μL
433,00 €
About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
151,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
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origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
affinity purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
polyclonal
purificado por
affinity chromatography
reactividad de especies
human, mouse
envase
antibody small pack of 25 μL
fabricante / nombre comercial
Upstate®
técnicas
immunoprecipitation (IP): suitable
western blot: suitable
isotipo
IgG
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
ambient
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PDGFRA(5156)
Descripción general
Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.
Especificidad
Recognizes PDGF Receptor alpha.
Inmunógeno
peptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor α
Aplicación
Detect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Calidad
routinely evaluated by immunoblot on 3T3/NIH cell lysate
Descripción de destino
150/170 kDa (doublet)
Forma física
ImmunoAffinity Purified
Protein A Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Nota de análisis
Control
HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue
HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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S Ugurel et al.
British journal of cancer, 92(8), 1398-1405 (2005-04-23)
This two-centre phase-II trial aimed at investigating the efficacy of imatinib in metastasised melanoma patients in correlation to the tumour expression profile of the imatinib targets c-kit and platelet-derived growth factor receptor (PDGF-R). The primary study end point was objective
K J Kurppa et al.
Oncogene, 35(10), 1283-1291 (2015-06-09)
Recent efforts to comprehensively characterize the mutational landscape of non-small cell lung cancer have identified frequent mutations in the receptor tyrosine kinase ERBB4. However, the significance of mutated ERBB4 in non-small cell lung cancer remains elusive. Here, we have functionally
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Biswas, SK; Zhao, Y; Nagalingam, A; Gardner, TW; Sandirasegarane, L
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Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells.
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