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N-008

Supelco

(−)-Nicotine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

(−)-Nicotine solution

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About This Item

Fórmula empírica (notación de Hill):
C10H14N2
Número de CAS:
54-11-5
Peso molecular:
162.23
Beilstein:
5733110
Número MDL:
MFCD00006369
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329818397
NACRES:
NA.24

grado

certified reference material

formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

1.0 mg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

forensics and toxicology

formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

CN1CCC[C@H]1c2cccnc2

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

Clave InChI

SNICXCGAKADSCV-JTQLQIEISA-N

Información sobre el gen

human ... CHRNA4(1137) , CHRNB2(1141)

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Categorías relacionadas

Descripción general

A Certified Spiking Solution® applicable for use in LC/MS or GC/MS applications such as nicotine testing, forensic analysis or clinical and diagnostic testing. Nicotine is a highly additive tobacco alkaloid associated with numerous health risks such as heart health, mental health and cancer.

Aplicación


  • Chiral nicotine for neuroreceptor research: S(−)-Nicotine solution is extensively used in neuroreceptor studies, particularly targeting cholinergic receptors. This enantiopure nicotine variant helps in understanding the binding affinity and activity differences between nicotine isomers, contributing to more targeted neuropharmacological interventions (Lu and Gao, 2024).

  • Pharmacological experiments in addiction research: The optically active form of S(−)-Nicotine is critical for addiction research, where it is used to investigate the pharmacodynamics and addictive properties of nicotine. Studies using this compound help in developing therapeutic strategies for smoking cessation and understanding the biochemical pathways involved in nicotine addiction (Yang et al., 2024).

  • Enantiomer specificity in biochemical studies: High purity S(−)-Nicotine is crucial for assays that require precise control over biochemical properties. Its application in cholinergic receptor assays helps to elucidate the specific interactions and effects of the S(−) enantiomer compared to its R(+) counterpart, thereby enhancing the accuracy of pharmacological models (Mancuso et al., 2024).

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jia Gao et al.
Cell death & disease, 12(6), 508-508 (2021-05-20)
There is limited and discordant evidence on the role of nicotine in diabetic vascular disease. Exacerbated endothelial cell dysregulation in smokers with diabetes is associated with the disrupted adipose function. Adipokines possess vascular protective, anti-inflammatory, and anti-diabetic properties. However, whether
Muhammed Ershad et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 16(4), 452-457 (2020-03-18)
Cigarettes and other tobacco products may be extinguished by submersion in liquids in beverage cans or bottles. Cases of nicotine poisoning in children have been reported following ingestion of such liquids. The aim of this study is to analyze the
Marina R Picciotto et al.
Neuropharmacology, 76 Pt B, 545-553 (2013-05-02)
Tobacco smoking in humans is one of the most persistent and widespread addictions and is driven by nicotine in tobacco smoke. Over the last several decades, understanding of the molecular and cellular basis for nicotine addiction has increased tremendously as
Christie D Fowler et al.
Neuropharmacology, 76 Pt B, 533-544 (2013-09-24)
Nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic dopamine system, and this action plays a critical in establishing and maintaining the tobacco smoking habit. Compounds that attenuate nicotine reward are considered promising therapeutic candidates for tobacco dependence, but many
Lindsay F Stead et al.
The Cochrane database of systematic reviews, 11, CD000146-CD000146 (2012-11-16)
The aim of nicotine replacement therapy (NRT) is to temporarily replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. The aims of this
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