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880346P

Avanti

DChemsPC

Avanti Research™ - A Croda Brand 880346P, powder

Sinónimos:

1,2-dicholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

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About This Item

Fórmula empírica (notación de Hill):
C70H116NO12P
Número de CAS:
1155878-69-5
Peso molecular:
1194.64
Código UNSPSC:
51191904
NACRES:
NA.25

Formulario

powder

envase

pkg of 1 × 25 mg (880346P-25mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 880346P

tipo de lípido

cardiolipins
phospholipids

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

O=P([O-])(OCC[N+](C)(C)C)OC[C@H](OC(CCC(OC1CC[C@]2(C)C(C1)=CCC3C2CC[C@]4(C)C3CC[C@H]4[C@@H](C)CCCC(C)C)=O)=O)COC(CCC(OC5CC[C@]6(C)C(C5)=CCC7C6CC[C@]8(C)C7CC[C@H]8[C@@H](C)CCCC(C)C)=O)=O

InChI

1S/C70H116NO12P/c1-46(2)16-14-18-48(5)57-24-26-59-55-22-20-50-42-52(32-36-67(50,7)61(55)34-38-69(57,59)9)81-64(73)29-28-63(72)78-44-54(45-80-84(76,77)79-41-40-71(11,12)13)83-66(75)31-30-65(74)82-53-33-37-68(8)51(43-53)21-23-56-60-27-25-58(49(6)19-15-17-47

Clave InChI

XIHPVFHVRYJTJV-DJTREBHPSA-N

Aplicación

DChemsPC might be used:
  • as a substitute for cholesterol in liposome formulation to study its effect on membrane stability
  • in the preparation of pH-gradient liposomes
  • to form sterol-phospholipid hybrid with palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (PCholPC) and to study its properties and interactions

Acciones bioquímicas o fisiológicas

Liposome instability in blood is caused mainly due to cholesterol exchange. Sterol modified phospholipid retains the bilayer-stabilizing effect of free cholesterol, inhibiting its transfer from the bilayer. Therefore, disterolphospholipids are ideal for liposome preparation. The use of DChemsPC in liposomes prevents content leaking into the serum.

Envase

5 mL Amber Glass Screw Cap Vial (880346P-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Vincent Forster et al.
Biomaterials, 33(13), 3578-3585 (2012-02-15)
Calcium channel blocker (CCB) overdose is potentially lethal. Verapamil and diltiazem are particularly prone to acute toxicity due to their dual effect on cardiac and vascular tissues. Unfortunately, conventional decontamination measures are ineffective in accelerating blood clearance and, to date
Michał Flasiński et al.
Langmuir : the ACS journal of surfaces and colloids, 32(16), 4095-4102 (2016-04-06)
The two synthetic sterol-phospholipid hybrids DCholPC and PCholPC were investigated in monolayers at the air/water interface. Study was based on π-A isotherm analysis complemented with application of grazing incidence X-ray diffraction. It was found that both compounds are capable of
Aditya G Kohli et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 86-93 (2013-12-26)
We introduce a method for tracking the rate and extent of delivery of liposome contents in vivo based on encapsulation of 4-methylumbelliferyl phosphate (MU-P), a profluorophore of 4-methylumbelliferone (MU). MU-P is rapidly dephosphorylated by endogenous phosphatases in vivo to form
Zhaohua Huang et al.
Angewandte Chemie (International ed. in English), 48(23), 4146-4149 (2009-05-09)
Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the
Maryam Iman et al.
International journal of pharmaceutics, 408(1-2), 163-172 (2011-02-01)
1,2-Di-stigma-steryl-hemi-succinoyl-sn-glycero-3-phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Since amphotericin B (AmB) interacts with sterols, we postulated that DSHemsPC could be used in
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