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860656P

Avanti

Lyso SM (d17:1)

Avanti Research™ - A Croda Brand 860656P, powder

Sinónimos:

Sphingosylphosphorylcholine (C17 base)

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About This Item

Fórmula empírica (notación de Hill):
C22H47N2O5P
Número de CAS:
118540-32-2
Peso molecular:
450.59
Código UNSPSC:
12352211
NACRES:
NA.25

formulario

powder

envase

pkg of 1 × 10 mg (860656P-10mg)
pkg of 1 × 5 mg (860656P-5mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 860656P

tipo de lípido

sphingolipids

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O

Categorías relacionadas

Descripción general

Lyso-sphingomyelin (Lyso SM) (d17:1), is an amphiphilic lysophospholipid with a long-chain sphingosine (C17 base) and a hydrophilic phosphorylcholine. Lyso SM, also known as sphingosylphosphorylcholine (SPC) is a de-acylated form of sphingomyelin, found in blood plasma.

Acciones bioquímicas o fisiológicas

Lyso-sphingomyelin (Lyso SM) is a vital lipid mediator, with an ability to regulate cell proliferation, migration, differentiation, metabolism and apoptosis. It exhibits various functions in cardiovascular system, immune system, central nervous system and skin. Increased concentration of Lyso SM has been observed in few disease states such as atopic dermatitis, Niemann-Pick disease (NPD) and cancer.

Envase

5 mL Amber Glass Screw Cap Vial (860656P-10mg)
5 mL Amber Glass Screw Cap Vial (860656P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Di Ge et al.
Acta pharmacologica Sinica, 39(12), 1830-1836 (2018-07-28)
Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid in blood plasma that is metabolized from the hydrolysis of the membrane sphingolipid. SPC maintains low levels in the circulation under normal conditions, which makes studying its origin and action difficult. In recent years
Wei-Lien Chuang et al.
Molecular genetics and metabolism, 111(2), 209-211 (2014-01-15)
Niemann-Pick disease type B (NPD-B) is caused by a partial deficiency of acid sphingomyelinase activity and results in the accumulation of lysosomal sphingomyelin (SPM) predominantly in macrophages. Notably, SPM is not significantly elevated in the plasma, whole blood, or urine
Hong-Wei Yue et al.
International journal of clinical and experimental medicine, 8(8), 11913-11921 (2015-11-10)
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an

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