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800819C

Avanti

18:0-22:6 DG

1-stearoyl-2-docosahexaenoyl-sn-glycerol, chloroform

Sinónimos:

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol; DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

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10 MG
256,50 €

256,50 €

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10 MG
256,50 €

About This Item

Fórmula empírica (notación de Hill):
C43H72O5
Número de CAS:
65886-80-8
Peso molecular:
669.03
Número MDL:
MFCD22570234
Código UNSPSC:
12352211
NACRES:
NA.25

256,50 €

Precio de catálogo513,00 €Ahorre 50 %
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
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Ensayo

>99% (TLC)

Formulario

liquid

envase

pkg of 1 × 5 mL (800819C-10mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 800819C

concentración

2 mg/mL (800819C-10mg)

tipo de lípido

neutral lipids
neutral glycerides

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.[1][2][3][4]
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

Aplicación

18:0-22:6 DG or 1-stearoyl-2-docosahexaenoyl-sn-glycerol has been used:
  • in the preparation of Golgi-like liposomes[5]
  • to study its effect on conventional protein kinase C (cPKC) and novel protein kinase C (nPKC) isozymes in vitro[6]
  • as a substrate for the measurement of diacylglycerol kinase η1 (DGKη1) activity in vitro[7]

Envase

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800819C-10mg)

Almacenamiento y estabilidad

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Otras notas

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Órganos de actuación

Central nervous system, Liver,Kidney

Clase de riesgo para el agua (WGK)

WGK 3

Listados normativos

Los listados normativos se proporcionan para los productos químicos principalmente. Para los productos no químicos sólo se puede proporcionar información limitada. Si no hay ninguna entrada, significa que ninguno de los componentes está en la lista. Es obligación del usuario garantizar el uso seguro y legal del producto.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificados de análisis (COA)

Lot/Batch Number

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Antoine Jaussaud et al.
Frontiers in plant science, 11, 48-48 (2020-03-03)
Diatoms are unicellular heterokonts, living in oceans and freshwaters, exposed to frequent environmental variations. They have a sophisticated membrane compartmentalization and are bounded by a siliceous cell-wall. Formation of lipid droplets (LDs), filled with triacylglycerol (TAG), is a common response
Matthew W Bunce et al.
The Journal of biological chemistry, 283(13), 8678-8686 (2008-01-26)
Phosphoinositide signaling pathways regulate numerous processes in eukaryotic cells, including migration, proliferation, and survival. The regulatory lipid phosphatidylinositol 4,5-bisphosphate is synthesized by two distinct classes of phosphatidylinositol phosphate kinases (PIPKs), the type I and II PIPKs. Although numerous physiological functions
Yuuna Kamiya et al.
Biochemistry and biophysics reports, 7, 361-366 (2016-07-20)
A variety of diacylglycerol (DG) molecular species are produced in stimulated cells. Conventional (α, βII and γ) and novel (δ, ε, η and θ) protein kinase C (PKC) isoforms are known to be activated by DG. However, a comprehensive analysis
Shu-Xin Zhang et al.
Cell research, 27(2), 253-273 (2017-01-21)
Neurite initiation is critical for neuronal morphogenesis and early neural circuit development. Recent studies showed that local actin aggregation underneath the cell membrane determined the site of neurite initiation. An immediately arising question is what signaling mechanism initiated actin aggregation.
Seung-Yeol Park et al.
Nature communications, 10(1), 3409-3409 (2019-08-01)
Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage
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