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710332C

Avanti

14:0 Cardiolipin (ammonium salt)

1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (ammonium salt), chloroform

Sinónimos:

1,1′,2,2′-tetramyristoyl cardiolipin (ammonium salt); 1,1′,2,2′-tetratetradecanoyl cardiolipin (ammonium salt); CL(1′-[14:0/14:0],3′-[14:0/14:0])

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About This Item

Fórmula empírica (notación de Hill):
C65H132N2O17P2
Número de CAS:
63988-20-5
Peso molecular:
1275.69
Código UNSPSC:
51191904
NACRES:
NA.25

Análisis

>99% (TLC)

formulario

solution

envase

pkg of 1 × 2.5 mL (710332C-25mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 710332C

concentración

10 mg/mL (710332C-25mg)

tipo de lípido

phospholipids
cardiolipins

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Categorías relacionadas

Descripción general

14:0 Cardiolipin is an acidic phospholipid. Structurally, cardiolipin comprises three glycerol moieties and four acyl chains and is localized in the inner membrane of mitochondria. 14:0 Cardiolipin contains four myristic acid as acyl chain.

Aplicación

14:0 Cardiolipin (1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (ammonium salt)) has been used:
  • as a standard in tandem mass spectrometry
  • in the preparation of membrane proximal region (MPR) of human immunodeficiency virus (HIV-1) glycoprotein 41 (gp41)-lipopeptide conjugate and liposomes
  • as a component of micelle for suspending C8 ceramide substrate in ceramide kinase assay

Acciones bioquímicas o fisiológicas

Cardiolipin (CL) plays a key role in oxidative phosphorylation. CL is essential for energy production and in the activation of apoptosis. Deficiency of CL is associated with the development of diabetes and age-related heart failure. Anomalies associated with CL composition is observed in Barth Syndrome (BTHS).

Envase

5 mL Clear Glass Sealed Ampule (710332C-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Órganos de actuación

Central nervous system, Liver,Kidney

Clase de riesgo para el agua (WGK)

WGK 3

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ninus Simonzadeh
Journal of chromatographic science, 47(4), 304-308 (2009-05-02)
Phospholipids, such as 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and 1,1',2,2'-tetramyristoyl cardiolipin, along with cholesterol, form liposomes in aqueous media and have been investigated at NeoPharm (Lake Bluff, IL) as drug-delivery systems. To accurately assess the effectiveness of various formulations involving the use of
Fang-Cheng Bi et al.
The Plant cell, 26(8), 3449-3467 (2014-08-26)
Arabidopsis thaliana plants that lack ceramide kinase, encoded by ACCELERATED CELL DEATH5 (ACD5), display spontaneous programmed cell death late in development and accumulate substrates of ACD5. Here, we compared ceramide accumulation kinetics, defense responses, ultrastructural features, and sites of reactive
Anja Stulz et al.
Langmuir : the ACS journal of surfaces and colloids, 35(49), 16366-16376 (2019-11-12)
Most antimicrobial peptides (AMPs) and their synthetic mimics (SMAMPs) are thought to act by permeabilizing cell membranes. For antimicrobial therapy, selectivity for pathogens over mammalian cells is a key requirement. Understanding membrane selectivity is thus essential for designing AMPs and
Alicja Bukowska et al.
European journal of pharmacology, 869, 172875-172875 (2019-12-27)
There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore, we aimed to investigate effects of exogenous FXa on mitochondrial and metabolic function as well as the
Joanna Juhaniewicz-Dębińska et al.
Langmuir : the ACS journal of surfaces and colloids, 36(19), 5324-5335 (2020-04-29)
Daptomycin is known as an effective antibiotic lipopeptide which shows activity against the number of Gram-positive pathogens. Its primary target is the bacterial cell membrane. However, the detailed mechanism of daptomycin action is still subject to debate. In this paper
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