700044P

7β-hydroxycholesterol-d7

Avanti Research^™ - A Croda Brand

• Sinónimos: cholest-5-ene-3b,7b-diol(d7)
• Fórmula empírica (notación de Hill): C₂₇H₃₉O₂D₇
• Número de CAS: 349553-97-5
• Peso molecular: 409.70
• Número MDL: MFCD03427682
• Código UNSPSC: 12352100
• NACRES: NA.25

Propiedades

• descripción: cholest-5-en-3β,7β-diol-d7
• Ensayo: >99% (TLC)
• Formulario: powder
• envase: pkg of 1 × 1 mg (700044P-1mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol.[1] 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.

Aplicación

7β-hydroxycholesterol-d7 has been used:

• as cholesterol oxidation product for mass spectroscopy analysis[2]
• as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis[3]
• as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry[4]
• as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification[5]

Acciones bioquímicas o fisiológicas

7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice.[6] 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.[1]

Envase

5 mL Amber Glass Screw Cap Vial (700044P-1mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids