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764787

Sigma-Aldrich

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1,000-1,000-1,000), lactide:glycolide 50:50

Sinónimos:

PLGA-PEG-PLGA

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About This Item

Código UNSPSC:
12162002
NACRES:
NA.23

descripción

typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)

formulario

liquid

cociente alimentación

lactide:glycolide 50:50

mol peso

PEG average Mn 1,000
PLGA average Mn 2000
average Mn (1,000-1,000-1,000)

marco temporal de la degradación

1-2 weeks

PDI

<1.2

temp. de almacenamiento

2-8°C

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Descripción general

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

Aplicación

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Características y beneficios

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCN7068
MKCG6095
MKCC8982
MKBX1132V
MKBT6439V

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Zhimei Song et al.
Journal of colloid and interface science, 354(1), 116-123 (2010-11-04)
The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

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