TPA-induced inhibition of gap junctional intercellular communication is not mediated through free radicals.: This research explores the role of N,N′-Diphenyl-p-phenylenediamine (DPPD) in cellular communication, providing insights into its applications in high-performance rubber stabilizers and life science manufacturing chemicals. (Hasler et al., 1990).
This study was undertaken in order to examine the roles of lipid peroxidation and poly (ADP-ribose) polymerase (PARP) activation in oxidant-induced renal cell death. Opossum kidney cell cultures were used as the renal epithelial cell model, and an inorganic hydroperoxide
Journal of pharmacological sciences, 111(4), 433-439 (2009-12-08)
Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea nitrogen
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 23(11), 1317-1320 (2007-11-14)
The oxidation of N,N'-diphenyl-1,4-phenylenediamine (DPPD) has been studied by cyclic voltammetry at glassy carbon electrodes in propylene carbonate. Next, the reaction between ammonia and DPPD was similarly investigated. It has been shown that ammonia reversibly removes protons from oxidized DPPD
Cultured rat hepatocytes and human hepatoma HepG2 cells were used to evaluate the hepatoprotective properties of polyphenolic extracts from the edible part of artichoke (AE). The hepatocytes were exposed to H2O2generated in situ by glucose oxidase and were treated with
The Journal of toxicological sciences, 31(3), 207-217 (2006-09-09)
Zinc is an essential nutrient that can also be toxic. We have previously reported that zinc-related renal toxicity is due, in part, to free radical generation in the renal epithelial cell line, LLC-PK(1) cells. We have also shown that an
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