222798
N-Methylbenzamide
≥99%
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About This Item
Fórmula lineal:
C6H5CONHCH3
Número de CAS:
Peso molecular:
135.16
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
NACRES:
NA.22
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Análisis
≥99%
formulario
solid
bp
167 °C/11 mmHg (lit.)
mp
76-78 °C (lit.)
solubilidad
ethanol: soluble 50 mg/mL, clear, yellow-green
cadena SMILES
CNC(=O)c1ccccc1
InChI
1S/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)
Clave InChI
NCCHARWOCKOHIH-UHFFFAOYSA-N
Descripción general
N-Methylbenzamide is a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.
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A series of N-methylbenzamide analogues (2-18) that is structurally derived from SR 48,968, a potent neurokinin-2 (NK(2)) receptor antagonist (pK(b)9.1), has been obtained using asymmetric synthesis. Isothiocyanato-N-methylbenzamide (10-12) and bromoacetamido-N-methylbenzamide derivatives (16-18) have been designed to serve as potential electrophilic
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