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Merck

GABRB3

gamma-aminobutyric acid (GABA) A receptor, beta 3

Sinónimos:
ECA5
Especie:
ID UniProtKB:
ID del gen:
  • Human(2562) Summary: This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
  • Mouse(14402) gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
  • Rat(24922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Zebrafish(566922) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • chicken(396290) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • Horse(100050803) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • cow(529593) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • dog(606913) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • sheep(101114905) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic cat(100286790) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • domestic guinea pig(100731340) gamma-aminobutyric acid (GABA) A receptor, beta 3
  • naked mole-rat(101711687) gamma-aminobutyric acid (GABA) A receptor, beta 3

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Gaboxadol hydrochloride, solid, ≥98% (HPLC),
Especie
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Especie
human
Isoguvacine hydrochloride, solid,
Especie
human
Piperidine-4-sulfonic acid, ,
Especie
human
Meprobamate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human

Small Molecule - Allosteric Modulator

Referencia del producto
Descripción
Especie
Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder,
Especie
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Especie
human
5α-Pregnan-3α-ol-11,20-dione, powder, ≥98% (TLC),
Especie
human
trans-Dehydroandrosterone, ≥99%,
Especie
human, rat
Midazolam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
Picrotoxin, powder,
Especie
human
Pregnenolone sulfate sodium salt, ,
Especie
human
SR-95531, ≥98% (HPLC), powder,
Especie
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Especie
human
trans-Dehydroandrosterone, ≥99%,
Especie
human, rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-GABRB3 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Aplicación
immunohistochemistry
western blot
Monoclonal Anti-GABRB3 antibody produced in mouse, clone S87-25, 1 mg/mL, purified immunoglobulin,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
western blot
Anti-GABRB3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
canine, human, mouse, rat
Aplicación
ELISA
immunohistochemistry

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
NO-711 hydrochloride, ≥98% (HPLC),
Especie
human
(±)-Vigabatrin, ,
Especie
human
2,6-Diisopropylphenol, 97%,
Especie
human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human

Small Molecule - Ligand

Referencia del producto
Descripción
Especie
Etomidate, >98% (HPLC), powder,
Especie
human
Flumazenil, >99% (HPLC), solid,
Especie
rat, human
Carbamazepine, powder,
Especie
rat, human
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human GABRB3,
Especie
human