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Merck

ADRA2A

adrenoceptor alpha 2A

Sinónimos:
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Especie:
ID UniProtKB:
ID del gen:
  • Human(150) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11551) adrenergic receptor, alpha 2a
  • Rat(25083) adrenoceptor alpha 2A
  • domestic guinea pig(100135475) adrenergic receptor, alpha 2a
  • chicken(428980) adrenergic, alpha-2A-, receptor
  • sheep(100170317) adrenoceptor alpha 2A
  • Domestic Rabbit(100009424) adrenoceptor alpha 2A
  • Zebrafish(266750) adrenergic, alpha-2A-, receptor
  • dog(486888) adrenoceptor alpha 2A
  • domestic cat(664736) adrenoceptor alpha 2A
  • sheep(101117291) adrenoceptor alpha 2A
  • naked mole-rat(101723298) adrenoceptor alpha 2A
  • cow(282135) adrenergic, alpha-2A-, receptor

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Clonidine hydrochloride, solid,
Especie
human
Xylazine hydrochloride, ≥99.0% (HPLC),
Especie
human
Guanfacine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Guanfacine hydrochloride, ≥98% (HPLC),
Especie
human
Guanabenz acetate salt, powder,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
1-Naphthylmethylamine, 97%,
Especie
rat
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Especie
human
1,2,3,4-Tetrahydroisoquinoline, 95%,
Especie
rat, human
Idazoxan hydrochloride, ,
Especie
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Adrenergic Receptor α-2A antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-ADRA2A antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
canine, human, mouse, rat
Aplicación
ELISA
immunocytochemistry

immunofluorescence
Anti-ADRA2A antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
ELISA
immunofluorescence
Anti-α2A Adrenergic Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, pig, rat
Aplicación
immunohistochemistry
western blot

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
Mianserin hydrochloride, ,
Especie
human
Agmatine sulfate salt, ≥97%, powder,
Especie
human

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
UK 14,304, ,
Especie
human
BP897, >98% (HPLC), solid,
Especie
human, rat
(−)-Norepinephrine, ≥98%, crystalline,
Especie
human, rat
Haloperidol, powder,
Especie
human, rat
Clozapine, ,
Especie
human, rat

Proteins

Referencia del producto
Descripción
Especie
ChemiSCREEN Human α2A Adrenergic Receptor Membrane Preparation, Human alpha2A GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Especie
human