Key Documents

(±)-4-Hydroxydebrisoquin sulfate

Name: (±)-4-Hydroxydebrisoquin sulfate
Brand: SIGMA
Price: 917 EUR

Synonym(s):

(±)-2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline sulfate, (±)-3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinecarboximidamide sulfate

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Pack Size	SKU	Availability	Price
5 mg		Please contact Customer Service for Availability	€917.00

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₃N₃O · 0.5H₂SO₄

CAS Number:

62580-84-1

Molecular Weight:

240.27

NACRES:

NA.77

PubChem Substance ID:

329827663

UNSPSC Code:

12161501

MDL number:

MFCD09840718

Form:

solid

Quality level:

200

€917.00

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Properties

form

solid

Quality Level

200

color

off-white

mp

267 °C

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NC(=N)N1CC(O)c2ccccc2C1.NC(=N)N3CC(O)c4ccccc4C3

InChI

1S/2C10H13N3O.H2O4S/c2*11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13;1-5(2,3)4/h2*1-4,9,14H,5-6H2,(H3,11,12);(H2,1,2,3,4)

InChI key

AETJLQVZNVTWPH-UHFFFAOYSA-N

Description

Application

(±)-4-Hydroxydebrisoquin sulfate can be used for the metabolic studies of debrisoquin.

Biochem/physiol Actions

CYP2D6 metabolite of debrisoquin.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item	N7251	C231	SML1970
Sigma-Aldrich UC261 (±)-4-Hydroxydebrisoquin sulfate	Sigma-Aldrich N7251 4-Nitrocatechol sulfate dipotassium salt	Sigma-Aldrich C231 CGP-20712A methanesulfonate salt	Sigma-Aldrich SML1970 PKUMDL-WQ-2101
form solid	form crystalline	form solid	form powder
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
color off-white	color yellow	color white to off-white	color light yellow to dark orange
mp 267 °C	mp -	mp -	mp -

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes.

L Bertilsson et al.

Pharmacogenetics, 3(2), 94-100 (1993-04-01)

Pronounced differences in the CYP2D6 gene between Chinese and Caucasians have previously been described. There was a low frequency of detrimental mutations in the Chinese CYP2D6 gene causing the poor metabolizer (PM) phenotype. In contrast to Caucasians where the Xba

In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver.

Miki Katoh et al.

Journal of pharmaceutical sciences, 96(2), 428-437 (2006-10-20)

We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In

Debrisoquine hydroxylation in Parkinson's disease.

M J Steiger et al.

Acta neurologica Scandinavica, 86(2), 159-164 (1992-08-01)

Debrisoquine (DBQ) metabolism was studied in 80 Parkinson's disease (PD) patients, 26 of whom had young onset Parkinson's disease (YOPD), and in 143 controls. There was no significant difference between the proportion of poor metabolisers of DBQ among YOPD patients

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Global Trade Item Number

SKU	GTIN
UC261-10MG	04061832932064
UC261-5MG	04061832932071

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(±)-4-Hydroxydebrisoquin sulfate

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About This Item

€917.00

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mp

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Biochem/physiol Actions

Packaging

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This Item

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pictograms

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pcodes

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flash_point_f

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ppe

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(±)-4-Hydroxydebrisoquin sulfate

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About This Item

UC261-5MG

€917.00

form

Quality Level

color

mp

storage temp.

SMILES string

InChI

InChI key

Application

Biochem/physiol Actions

Packaging

Compare Similar Items

This Item

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Global Trade Item Number

Questions

Reviews

Active Filters