Intensified and Continuous Downstream Processing
Gain operational efficiency and flexibility while reducing footprint and costs
Intensify Your Downstream Process
Make the right decision and intensify your downstream process to maximize flexibility and increase productivity.
Intensified, closed, and continuous bioprocessing are foundational strategies for maximizing operational flexibility and increasing productivity in mAb and recombinant protein manufacturing.
With a full suite of solutions designed to meet the increased demands of intensified downstream processes and the support of our experienced technical teams, we can help you choose the best strategy to realize the benefits of downstream process intensification .
Intensified & Continuous Downstream Processing
Intensified & Continuous Downstream Processing
Today’s biopharmaceutical manufacturers face numerous challenges:
- Flexibility in manufacturing operations to adjust manufacturing capacity to meet drug production needs
- High volumetric productivity with a smaller facility footprint
- Speed-to-market and cost-efficient production for competitive advantage
- Agility to process multiple products in a single facility
Downstream process intensification can deliver gains in productivity while maintaining product quality. From initial capture using multicolumn chromatography systems to flow through polishing with ion exchange resins and membranes, our solutions for downstream intensification take advantage of closed processing technologies to mitigate contamination and safety risks, and maximize facility asset utilization.
Whether you’re intensifying your batch processing or moving towards next generation continuous processing, our integrated downstream solutions will help get you there. When combined with our automation and control software that delivers improved automation and control, you’ll be ready to meet the expectations for facility of the future and Biopharma 4.0.
With help and technical support from our experienced global team we will empower you to make the right decisions faster.
Related Categories
Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules.
Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume.
Ion exchange (IEX) chromatography separates biomolecules based on charge differences between the target molecule and chromatography resin.
Optimize downstream purification using membrane chromatography for capture and polishing. Natrix® chromatography membranes boost economics and facility efficiency.
Elevate Filtration Precision: Our tangential flow products ensure purity for mAbs, vaccines, and more, scaling from single-use to multi-use.
Buffers and pH adjusters play a critical role in controlling pH from media preparation to final fill and finish.
Related Resources
- Closed Processing for Biomanufacturing
Mitigate contamination and safety risks, maximize new and existing facility and asset utilization, while enabling sustainable multi-modal manufacturing.
- Value Drivers and Benefits of Closed Processing
Closed processing enables more streamlined, flexible, and cost-effective multi-product and multi-modal facilities, while ensuring the highest level of product quality and safety. Learn more about how contamination risk is mitigated and the additional value and benefits of closed processing.
BioContinuum™ Platform: Your enabler of the biomanufacturing facility of the future!
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