The solubility of M149 Sigma-Aldrich Methiothepin mesylate salt has not been tested in salt water.
As per our website and the CofA, the solubility is in H2O: 13 mg/mL
https://www.sigmaaldrich.com/US/en/product/sigma/m149#product-documentation
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/M149-100MG0000494391.pdf
M149
Methiothepin mesylate salt
≥98% (HPLC), solid
Synonym(s):
1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Please contact Customer Service for Availability | €115.00 | |
| 250 mg | Please contact Customer Service for Availability | €253.00 |
About This Item
Linear Formula:
C20H24N2S2 · CH3SO3H
CAS Number:
Molecular Weight:
452.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: 13 mg/mL
SMILES string
CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1
InChI
1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)
InChI key
CZMDZGZYKOGLJY-UHFFFAOYSA-N
Gene Information
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)
General description
Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.
Application
Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.
Biochem/physiol Actions
Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| form solid | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| solubility H2O: 13 mg/mL | solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >21 mg/mL | solubility H2O: 20 mg/mL, clear | solubility H2O: 2 mg/mL, clear |
| storage condition desiccated | storage condition - | storage condition desiccated | storage condition - |
| color white | color white | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
Yuan Lai et al.
Neurobiology of learning and memory, 173, 107278-107278 (2020-07-12)
Conditioned taste aversion (CTA) learning induces the devaluation of a preferred food through its pairing with a stimulus inducing internal illness. In invertebrates, it is still unclear how this aversive learning impairs the memories of stimuli that had been associated
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABN1773 | 04055977181630 |
| M149-100MG | 04061834040682 |
| M149-250MG | 04061834040699 |
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What is the solubility of M149 in salt water?
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