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C5235

Cytochrome P450 human

4F3B isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.47
EC Number:
1.6.2.4 (BRENDA, IUBMB)
MDL number:
MFCD03456520
Biological source:
human
Recombinant:
expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

form

solution

mol wt

45-60 kDa

packaging

vial of 0.5 nmol

UniProt accession no.

Q08477

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CYP4F3(4051)

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous. The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin. Cytochrome P450 (CYP) plays an important role in detoxifying xenobiotics, cellular metabolism and homeostasis. One of the main mechanisms of drug-drug interactions is the induction or inhibition of these enzymes. CYP enzymes are transcriptionally activated by a variety of xenobiotics and by endogenous substrates via receptor-dependent pathways. Inhibition of these enzymes is a major factor in metabolism-based drug-drug interactions, and many chemotherapeutic medications can cause drug interactions by either inhibiting or inducing the cytochrome p450 enzyme system.
The CYP4F3B isoform catalyzes the 20-hydroxylation of leukotriene B4.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Other Notes

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.

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Cytochrome P450 human 4F3B isozyme microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

Sigma-Aldrich

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Sigma-Aldrich

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Cytochrome P450 human

Cytochrome P450 human 1B1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

Sigma-Aldrich

C3860

Cytochrome P450 human

biological source

human

biological source

human

biological source

human

biological source

human

Gene Information

human ... CYP4F3(4051)

Gene Information

human ... CYP3A4(1576)

Gene Information

human ... CYP1A1(1543)

Gene Information

human ... CYP1B1(1545)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

application(s)

cell analysis

application(s)

cell analysis

application(s)

cell analysis

application(s)

cell analysis

form

solution

form

solution

form

solution

form

solution

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM6409
SLCM5658
SLCM4553
SLCM7542
SLBX5173

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P Christmas et al.
The Journal of biological chemistry, 274(30), 21191-21199 (1999-07-20)
Cytochrome P450 4F3 (CYP4F3) catalyzes the inactivation of leukotriene B(4) by omega-oxidation in human neutrophils. To understand the regulation of CYP4F3 expression, we analyzed the CYP4F3 gene and cloned a novel isoform (CYP4F3B) that is expressed in fetal and adult
Xiangrong Zhang et al.
PloS one, 9(4), e94962-e94962 (2014-04-17)
The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes. 20(R)-25-OCH3-PPD was incubated with liver microsomes in the presence of NADPH. The reaction mixtures and the metabolites were identified
Dongju Lin et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1727-1736 (2014-07-16)
Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms
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Global Trade Item Number

SKUGTIN
C5235-1VL04061838112866

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