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Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone

Name: Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone
Brand: SIGMA
Price: 594 EUR

powder, ≥95%

Synonym(s):

Z-VDVAD-FMK

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Pack Size	SKU	Availability	Price
1 mg		Please contact Customer Service for Availability	€594.00

About This Item

Linear Formula:

C₃₂H₄₆N₅O₁₁F

CAS Number:

210344-92-6

Molecular Weight:

695.73

NACRES:

NA.77

PubChem Substance ID:

329774898

UNSPSC Code:

12352209

MDL number:

MFCD03452881

€594.00

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Properties

biological source

synthetic (organic)

Quality Level

200

assay

≥95%

form

powder

color

white

solubility

DMSO: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(=O)CF

InChI

1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21-,22-,26-,27-/m0/s1

InChI key

ANTIWMNLIROOQF-IREHUOSBSA-N

Gene Information

human ... CASP2(835)
mouse ... CASP2(12366)
rat ... CASP2(64314)

Description

Biochem/physiol Actions

A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.

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1 of 1

This Item	C1480	C1230	C2105
Sigma-Aldrich C1605 Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone	Sigma-Aldrich C1480 Z-Phe-Ala fluoromethyl ketone	Sigma-Aldrich C1230 Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone	Sigma-Aldrich C2105 Z-Val-Ala-Asp fluoromethyl ketone
assay ≥95%	assay ≥90% (TLC)	assay ≥90% (TLC)	assay ≥90% (TLC)
biological source synthetic (organic)	biological source -	biological source synthetic (organic)	biological source -
Gene Information human ... CASP2(835) mouse ... CASP2(12366) rat ... CASP2(64314)	Gene Information -	Gene Information -	Gene Information -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form powder
solubility DMSO: soluble	solubility DMSO or DMF: 20 mM	solubility methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow	solubility -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation.

Wolfgang W Quitschke

PloS one, 7(6), e39568-e39568 (2012-07-07)

Curcumin preparations typically contain a mixture of polyphenols, collectively referred to as curcuminoids. In addition to the primary component curcumin, they also contain smaller amounts of the co-extracted derivatives demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids can be differentially solubilized in serum, which

A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway.

Mingxing Tian et al.

Veterinary microbiology, 244, 108648-108648 (2020-05-14)

Brucella is a facultative intracellular bacterium, dividing into smooth- and rough-type Brucella. Smooth-type Brucella can dissociate into rough mutants with cytotoxicity for macrophages during infection, which is critical for Brucella egress and dissemination. However, the mechanism of cytotoxicity infected by

Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells.

Aitziber Buqué et al.

Molecular cancer, 11, 25-25 (2012-04-28)

Metastatic melanoma is a lethal skin cancer and its incidence is rising every year. It represents a challenge for oncologist, as the current treatment options are non-curative in the majority of cases; therefore, the effort to find and/or develop novel

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Global Trade Item Number

SKU	GTIN
C1605-1MG	04061826674017

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Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone

powder, ≥95%

Select a Size

About This Item

€594.00

biological source

Quality Level

assay

form

color

solubility

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Compare Similar Items

This Item

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

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Skip To

Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone

powder, ≥95%

Select a Size

About This Item

C1605-1MG

€594.00

biological source

Quality Level

assay

form

color

solubility

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Compare Similar Items

This Item

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Global Trade Item Number

Questions

Reviews

Active Filters