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A2853

Azoxymethane

Practical grade, 13.4 M, ≥90% (GC)

Synonym(s):

AOM

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About This Item

Linear Formula:
CH3N=N(→O)CH3
CAS Number:
25843-45-2
Molecular Weight:
74.08
UNSPSC Code:
12352200
PubChem Substance ID:
24890698
MDL number:
MFCD00126912
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assay

≥90% (GC)

quality

Practical grade

contains

≤15% ethanol and acetic acid (Packaged based on azoxymethane.)

composition

methylene chloride, ≤5%

concentration

13.4 M

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

Biochem/physiol Actions

Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

75-09-2

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
089K1157
079K1133
098K1469
098K1488
038K1557

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Kazuto Yoshimi et al.
BMC cancer, 12, 448-448 (2012-10-04)
Chemotherapeutic bioassay for colorectal cancer (CRC) with a rat model bearing chemically-induced CRCs plays an important role in the development of new anti-tumor drugs and regimens. Although several protocols to induce CRCs have been developed, the incidence and number of
Takuji Tanaka et al.
Seminars in immunopathology, 35(2), 245-254 (2012-09-21)
Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible
Jiezhong Chen et al.
Cancer biology & therapy, 8(14), 1313-1317 (2009-06-09)
Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors.
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