04473
2,4-Pyridinedicarboxylic acid
≥98.0%
Synonym(s):
Lutidinic acid
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 g | Please contact Customer Service for Availability | €220.00 €165.00 |
About This Item
Empirical Formula (Hill Notation):
C7H5NO4
CAS Number:
Molecular Weight:
167.12
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
207-892-2
MDL number:
Beilstein/REAXYS Number:
131631
€165.00
List Price€220.00Save 25%Please contact Customer Service for Availability
Quality Level
assay
≥98.0%, 98.0-102.0% (T)
InChI
1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChI key
MJIVRKPEXXHNJT-UHFFFAOYSA-N
Application
2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. . 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98.0%, 98.0-102.0% (T) | assay - | assay ≥99.5% (T) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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M Kristian Koski et al.
The Journal of biological chemistry, 282(51), 37112-37123 (2007-10-18)
Prolyl 4-hydroxylases (P4Hs) are 2-oxoglutarate dioxygenases that catalyze the hydroxylation of peptidyl prolines. They play an important role in collagen synthesis, oxygen homeostasis, and plant cell wall formation. We describe four structures of a P4H from the green alga Chlamydomonas
Line H Kristensen et al.
The FEBS journal, 279(11), 1905-1914 (2012-03-17)
Dynamic methylations and demethylations of histone lysine residues are important for gene regulation and are facilitated by histone methyltransferases and histone demethylases (HDMs). KDM5B/Jarid1B/PLU1 is an H3K4me3/me2-specific lysine demethylase belonging to the JmjC domain-containing family of histone demethylases (JHDMs). Several
G Tschank et al.
The Biochemical journal, 275 ( Pt 2), 469-476 (1991-04-15)
The biochemical and morphological consequences of procollagen prolyl 4-hydroxylase inhibition by pyridine-2,4-dicarboxylic acid (2,4-PDCA) and its diethyl ester (diethyl-2,4-PDC) were studied in chick-embryo calvaria, which predominantly synthesize type I collagen. Half-maximal inhibition of tissue hydroxyproline formation required 650 microM-2,4-PDCA, whereas
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 143618-100G | 04061838734921 |
| 143618-500G | 04061832278599 |
| 04473-5G | 04061838630681 |