218735

Caspase Inhibitor II

The Caspase Inhibitor II, also referenced under CAS 147837-52-3, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Caspase Inhibitor II, Ac-VAD-CHO
• Empirical Formula (Hill Notation): C₁₄H₂₃N₃O₆
• CAS Number: 147837-52-3
• Molecular Weight: 329.35
• MDL number: MFCD00672421
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 150 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C14H23N3O6/c1-7(2)12(16-9(4)19)14(23)15-8(3)13(22)17-10(6-18)5-11(20)21/h6-8,10,12H,5H2,1-4H3,(H,15,23)(H,16,19)(H,17,22)(H,20,21)/t8-,10-,12-/m0/s1
• InChI key: BGFYQRSQECIBIB-PEXQALLHSA-N

Description

General description

A potent and reversible inhibitor of caspases.

A potent and reversible pan-caspase inhibitor.

Biochem/physiol Actions

Cell permeable: no

Primary Target
pan-caspase

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Val-Ala-Asp-CHO

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable