T2573

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

• Sinónimos: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045
• Fórmula empírica (notación de Hill): C₂₄H₂₇NO₅S
• Número de CAS: 97322-87-7
• Peso molecular: 441.54
• Número MDL: MFCD00878416
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724629
• NACRES: NA.77

Propiedades

• Nombre del producto: Troglitazone, ≥98% (HPLC)
• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to off-white
• solubilidad: DMSO: 20 mg/mL
• cadena SMILES: Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
• Clave InChI: GXPHKUHSUJUWKP-UHFFFAOYSA-N
• Información sobre el gen: human ... PPARA(5465) , PPARG(5468)

Descripción

Descripción general

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

Aplicación

Troglitazone has been used as a reagent in adipocyte differentiation medium.

Acciones bioquímicas o fisiológicas

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

Características y beneficios

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles¹. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α².

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)