T2265

Tetraethylammonium chloride

≥98% (titration)

• Sinónimos: TEA chloride
• Fórmula lineal: (C₂H₅)₄N(Cl)
• Número de CAS: 56-34-8
• Peso molecular: 165.70
• Beilstein: 3563247
• Número CE: 200-267-5
• Número MDL: MFCD00011828
• Código UNSPSC: 12352107
• ID de la sustancia en PubChem: 24277874
• NACRES: NA.32

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥98% (titration)
• Formulario: powder
• técnicas: blocking: suitable
• color: white to light yellow
• cadena SMILES: [Cl-].CC[N+](CC)(CC)CC
• InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
• Clave InChI: YMBCJWGVCUEGHA-UHFFFAOYSA-M
• Información sobre el gen: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

Descripción

Aplicación

Tetraethylammonium chloride (TEAC) has been used:

• used for inhibition of peroxynitrite induced relaxation in rat aorta rings[1]
• as a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neurons[2]
• for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties[3]

Acciones bioquímicas o fisiológicas

Blocks K⁺ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents.

Tetraethylammonium chloride (TEAC) blocks K⁺ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite.[1] It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients.[4] TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals.[5] TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).[6]

Precaución

moisture sensitive, handle under argon

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 201.2 °F - closed cup
• Punto de inflamabilidad (°C): 94 °C - closed cup
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves