SML1529

Erdosteine

≥98% (HPLC), powder, mucolytic agent

• Sinónimos: ({2-Oxo-2-[(2-oxotetrahydro-3-thienyl)amino]ethyl}sulfanyl)acetic acid, 2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid
• Fórmula empírica (notación de Hill): C₈H₁₁NO₄S₂
• Número de CAS: 84611-23-4
• Peso molecular: 249.31
• Número MDL: MFCD00867664
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825946
• NACRES: NA.77

Propiedades

• Nombre del producto: Erdosteine, ≥98% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 20 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: S1CCC(C1=O)NC(=O)CSCC(=O)O
• InChI: 1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)
• Clave InChI: QGFORSXNKQLDNO-UHFFFAOYSA-N

Descripción

Descripción general

Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.

Aplicación

Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1β-stimulated inflammation in rat chondrocytes in osteoarthritis models.

Acciones bioquímicas o fisiológicas

Erdosteine is a mucolytic drug with expectorant and antitussive effects.

Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable