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SML0884

bpV(HOpic)

Name: bpV(HOpic)
Brand: SIGMA

≥90% V basis

Sinónimos:

Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K₂[VO(O₂)2C₆H₄NO₃]

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Fórmula empírica (notación de Hill):

K₂VOO₂O₂C₆H₄NO₃

Número CAS:

722494-26-0

Peso molecular:

347.24

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥90% V basis

Form:

powder

Storage condition:

desiccated, protect from light

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Propiedades

Quality Segment

100

assay

≥90% V basis

form

powder

storage condition

desiccated, protect from light

color

faintly yellow to dark yellow

solubility

H₂O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

[V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O

InChI

1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1

InChI key

HSCJTESZNNRNPK-UHFFFAOYSA-M

Descripción

Application

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.

Biochem/physiol Actions

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.

Other Notes

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

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Este artículo	203701	SML0885	SML0889
Sigma-Aldrich SML0884 bpV(HOpic)	Sigma-Aldrich 203701 bpV(HOpic)	Sigma-Aldrich SML0885 bpV(pic)	Sigma-Aldrich SML0889 bpV(phen)
description ≥90% V basis	description A potent phosphotyrosine phosphatase inhibitor.	description ≥95% V basis	description ≥95% V basis
form powder	form solid	form powder	form powder
assay ≥90% V basis	assay ≥70% (⁵¹V-NMR)	assay ≥95% V basis	assay ≥95% V basis
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 20 mg/mL, clear	solubility water: 4 mg/mL	solubility H₂O: 20 mg/mL, clear	solubility H₂O: 20 mg/mL, clear
storage condition protect from light, desiccated	storage condition OK to freeze, protect from light	storage condition protect from light	storage condition protect from light