203701

bpV(HOpic)

A potent phosphotyrosine phosphatase inhibitor.

• Sinónimos: bpV(HOpic), Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
• Fórmula lineal: K₂[VO(O₂)₂C₆H₄NO₃] · 4H₂O
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥70% (⁵¹V-NMR)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propiedades

• assay: ≥70% (⁵¹V-NMR)
• form: solid
• potency: 14 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: water: 4 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC₅₀ = 14 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
PTEN

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable