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Merck
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Documentos clave

SMB00607

Sigma-Aldrich

Amoxicillin trihydrate: potassium clavulanate (4:1)

Sinónimos:

Amoxicillin Trihydrate: Potassium Clavulanate

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About This Item

Código UNSPSC:
51285005
NACRES:
NA.85

Formulario

powder

Nivel de calidad

200

condiciones de almacenamiento

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

color

white to yellow

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

cell wall synthesis | interferes

temp. de almacenamiento

2-8°C

Descripción general

Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.

Aplicación

Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.

Acciones bioquímicas o fisiológicas

Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.

Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.

Envase

1G

Componentes

Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.

Almacenamiento y estabilidad

Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.

Pictogramas

FlameHealth hazard
GHS02,GHS08

Palabra de señalización

Danger

Frases de peligro

H228,H252,H317,H334

Clasificaciones de peligro

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

Riesgos supl.

EUH014,EUH044

Código de clase de almacenamiento

4.2 - Pyrophoric and self-heating hazardous materials

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
0000410521
0000410521
0000368640
0000368640
0000209520

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Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

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Preparation and characterization of Sn/Zn/TiO2 photocatalyst for enhanced amoxicillin trihydrate degradation
Mohammadi R, et al.
Desalination and Water Treatment, 53(7), 1995-2004 (2015)
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, et al.
Cell (2018)
A P Ball et al.
Lancet (London, England), 1(8169), 620-623 (1980-03-22)
Clavulanic acid is an inhibitor of certain beta-lactamases, notably those enzymes which inactivate the penicillins and cause resistance of important bacteria to these antibiotics. Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.
H C Neu et al.
Antimicrobial agents and chemotherapy, 10, 407-410 (1970-01-01)
R N Brogden et al.
Drugs, 18(3), 169-184 (1979-09-01)
Amoxycillin, an acid stable semisynthetic penicillin shown to be effective against a wide range of infections when given orally, is now available for intramuscular and intravenous injection. Amoxycillin has an antibacterial spectrum and level of activity essentially the same as
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