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R108

Sigma-Aldrich

Ro 41-0960

solid

Sinónimos:

2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone

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About This Item

Fórmula empírica (notación de Hill):
C13H8FNO5
Número de CAS:
125628-97-9
Peso molecular:
277.20
MDL number:
MFCD00078597
UNSPSC Code:
12352200
PubChem Substance ID:
24278193
NACRES:
NA.77

form

solid

Quality Level

100

storage condition

protect from light

color

yellow

solubility

H2O: slightly soluble <0.7 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL
ethanol: soluble

storage temp.

2-8°C

SMILES string

Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F

InChI

1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H

InChI key

RQPAUNZYTYHKHA-UHFFFAOYSA-N

Gene Information

human ... COMT(1312)

Application

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.

Biochem/physiol Actions

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Store tightly sealed at 4 °C, protected from exposure to light.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Majorie B M van Duursen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 81(2), 316-324 (2004-07-16)
Phytochemicals are natural dietary constituents of fruits and vegetables. Some of these phytochemicals are known to affect estrogen-metabolizing enzymes. In breast tissue, estradiol can be metabolized to the catechol estrogens 2- and 4-hydroxyestradiol (2-OHE(2) and 4-OHE(2)). Catechol estrogens are suspected
J A Lavigne et al.
Cancer research, 61(20), 7488-7494 (2001-10-19)
Many of the major identified risk factors for breast cancer are associated with exposure to endogenous estrogen. In addition to the effects of estrogen as a growth factor, experimental and epidemiological evidence suggest that catechol metabolites of estrogen also contribute
J W Miller et al.
Clinical neuropharmacology, 20(1), 55-66 (1997-02-01)
L-Dopa is the most effective drug known for the treatment of Parkinson's disease. However, the large doses required to treat this neurodegenerative disorder can significantly affect tissue concentrations of sulfur amino acid metabolites due to peripheral and central O-methylation. These
A Storch et al.
Molecular pharmacology, 57(3), 589-594 (2000-02-29)
Inhibition of catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a new therapeutic strategy in the treatment of Parkinson's disease. However, nothing is known about the effects of COMT inhibition on levodopa (L-dopa)-induced toxicity in dopamine (DA) neurons. Therefore we evaluated the effects
M H Hassan et al.
Human reproduction (Oxford, England), 26(11), 3008-3018 (2011-09-08)
Uterine leiomyomas (fibroids) are the most common pelvic tumors in women. We assessed the potential therapeutic utility of Ro 41-0960, a synthetic catechol-O-methyl transferase inhibitor (COMTI), in the Eker rat. We randomized uterine fibroid-bearing Eker rats for treatment with Ro
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