A4377

S-(5′-Adenosyl)-L-methionine iodide

≥80% (spectrophotometric assay), suitable for cell culture

• Sinónimos: AdoMet, SAM
• Fórmula empírica (notación de Hill): C₁₅H₂₃IN₆O₅S
• Número CAS: 3493-13-8
• Peso molecular: 526.35
• NACRES: NA.26
• PubChem Substance ID: 24890852
• UNSPSC Code: 12352209
• EC Number: 222-486-5
• MDL number: MFCD00043192
• Beilstein/REAXYS Number: 4120787

Propiedades

• Nombre del producto: S-(5′-Adenosyl)-L-methionine iodide, ≥80% (HPLC), ≥80% (spectrophotometric assay)
• Quality Segment: 200
• assay: ≥80% (HPLC), ≥80% (spectrophotometric assay)
• form: powder
• technique(s): cell culture | mammalian: suitable
• color: white to off-white
• solubility: H₂O: 100 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [I-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1
• InChI key: XQMWYLXPEGFCFT-XKGORWRGSA-N

Descripción

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Analysis Note

Purity based on UV and HPLC.

Disclaimer

This material is very unstable at room temperature.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type N95 (US)