N0636

Nicotinamide

BioReagent, suitable for cell culture, suitable for insect cell culture

• Sinónimos: Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• Fórmula empírica (notación de Hill): C₆H₆N₂O
• Número de CAS: 98-92-0
• Peso molecular: 122.12
• Beilstein: 383619
• Número CE: 202-713-4
• Número MDL: MFCD00006395
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 24897434
• NACRES: NA.75

Propiedades

• origen biológico: synthetic (organic)
• Línea del producto: BioReagent
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• mol peso: M_w 122.12 g/mol
• técnicas: cell culture | insect: suitable; cell culture | mammalian: suitable
• color: white
• mp: 128-131 °C (lit.)
• solubilidad: water: soluble 50 mg/mL, clear, colorless
• cadena SMILES: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
• Clave InChI: DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Información sobre el gen: human ... PARP1(142) , SIRT2(22933)

Descripción

Descripción general

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Aplicación

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.

Acciones bioquímicas o fisiológicas

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 302.0 °F - closed cup
• Punto de inflamabilidad (°C): 150 °C - closed cup
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves