N0513
Nerve Growth Factor-7S from murine submaxillary gland
lyophilized powder, suitable for cell culture
Sinónimos:
NGF-7S
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About This Item
Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77
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Nombre del producto
Nerve Growth Factor-7S from murine submaxillary gland, NGF-7S, lyophilized powder, suitable for cell culture
origen biológico
mouse
Nivel de calidad
Formulario
lyophilized powder
potencia
2-250 ng/mL ED50/EC50
calidad
endotoxin tested
mol peso
protein 130 kDa
envase
pkg of 0.1 mg
técnicas
cell culture | mammalian: suitable
impurezas
≤10
color
white
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Ngf(18049)
Descripción general
Nerve growth factor (NGF) is a dimer of 118-residue polypeptide chains linked non-covalently. Both these polypeptides contain three intramolecular disulphide bridges. It forms the prototype of the neurotrophin growth factor family. In male mouse submandibular salivary gland, NGF is present in high amounts, and is present as a high molecular weight complex called nerve growth factor-7S (NGF-7S). NGF-7S is an α2β2γ2 complex, where β2-NGF is the active neurotrophin, and is linked to the dimers of the glandular kallikrein serine proteinases members, α-NGF and γ-NGF.
Aplicación
Nerve Growth Factor-7S (NGF-7S) from murine submaxillary gland has been used for the treatment of following cells to induce neuronal differentiation-
- PC12
- Dorsal root ganglia (DRG) obtained from chick embryos of either sex (Gallus gallus)
Acciones bioquímicas o fisiológicas
Nerve growth factor (NGF) is a neurotrophin, which facilitates the differentiation and survival of specific subtypes of neurons of central nervous system and peripheral nervous system. However, nerve growth factor-7S (NGF-7S) lacks any neurotrophic activity as most part of β-NGF subunit is buried within the NGF-7S complex.
Forma física
Lyophilized from 0.2 μm filtered solution in 25 mM sodium phosphate, pH 7.0.
Nota de preparación
Nerve growth factor-7S (NGF-7S) is isolated from male mouse submaxillary glands using a modification of the method of Varon, et al.
Nota de análisis
The biological activity is measured using a 3-day MTT assay.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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