M4002

6-Methylmercaptopurine riboside

≥99% (HPLC)

• Sinónimos: 6MMPr, 6-(Methylthio)-9-β-D-ribofuranosyl-9H-purine
• Fórmula empírica (notación de Hill): C₁₁H₁₄N₄O₄S
• Número de CAS: 342-69-8
• Peso molecular: 298.32
• Número CE: 206-442-2
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 24896894
• NACRES: NA.51

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥99% (HPLC)
• Formulario: powder
• solubilidad: methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@H]([C@@H](CO)O1)[C@@H](O)[C@@H]1N2C=NC3=C(SC)N=CN=C32
• InChI: 1S/C11H14N4O4S/c1-20-10-6-9(12-3-13-10)15(4-14-6)11-8(18)7(17)5(2-16)19-11/h3-5,7-8,11,16-18H,2H2,1H3
• Clave InChI: ZDRFDHHANOYUTE-UHFFFAOYSA-N

Descripción

Aplicación

6-Methylmercaptopurine riboside (6MMPR) has been used as a phosphoribosyl pyrophosphate amidotransferase inhibitor to study its effects on DNA replication in a retinoblastoma (Rb) phosphorylation-independent manner in human cytomegalovirus (HCMV) [1], as a purine analog to determine its effects on angiogenesis of endothelial cells induced by fibroblast growth factor 2 (FGF2) in vitro and in vivo[2], as a metabolite of 6-methylmercaptopurine to determine its levels in human plasma by high-performance liquid chromatography (HPLC) method [3].

6-Methylmercaptopurine riboside (6MMPr) is used in studies on thiopurine metabolism by enzymes such as inosine-5′-monophosphate dehydrogenase and thiopurine methyltransferase. 6MMPr may also be used to study mechanisms of bovine viral diarrhea virus (BVDV) inhibition.

Acciones bioquímicas o fisiológicas

6-Methylmercaptopurine riboside (6MMPR) is a modified thiopurine nucleoside involved in the inhibition of purine synthesis. It exhibits anti-viral effects against various viruses.[4] 6MMPR is an analog of purine and an inhibitor of nerve growth factor-activated protein kinase N.[2]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)