Benzidine (4,4′-Diaminobiphenyl) is an environmental genotoxin that posses increased risks of cancer to exposed people. Benzidine may be used as a reference material in procedures that analyze for benzidine. Benzidine can be used in studies on its mechanisms of genotoxicity.
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Tumor initiator in mammary glands of experimental animal.[1]
To evaluate the role of metabolism in benzidine (BZ) carcinogenesis, BZ and 2 or its metabolites, N,N'-diacetylbenzidine and N-hydroxy-N,N'-diacetylbenzidine (NOHDABZ), were given by i.p. injection to female CD rats twice weekly for 4 weeks beginning at 30 days of age.
Stem cells and development, 24(22), 2660-2673 (2015-07-17)
Autophagy is required for hematopoietic stem cell multilineage differentiation, but the underlying mechanism is unknown. Using a conditional mouse model and human leukemia cells, we uncovered a mechanistic link between autophagy and hematopoietic stem cell differentiation. Loss of autophagy in
Bloodstains often constitute the major physical evidence in crime investigation. Diluted blood invisible to the naked eye can be detected through presumptive tests however such tests can damage samples and prevent further processing such as DNA analysis. In this study
Chemistry (Weinheim an der Bergstrasse, Germany), 18(37), 11828-11836 (2012-07-26)
Salts that contain radical cations of benzidine (BZ), 3,3',5,5'-tetramethylbenzidine (TMB), 2,2',6,6'-tetraisopropylbenzidine (TPB), and 4,4'-terphenyldiamine (DATP) have been isolated with weakly coordinating anions [Al(OR(F))(4)](-) (OR(F) = OC(CF(3))(3)) or SbF(6)(-). They were prepared by reaction of the respective silver(I) salts with stoichiometric
This study reports fabrication and characterization of nanoscale organic light emitting diodes with reduced charge spreading. Nanoimprint lithography is used to make SU-8 nanochannels with approximately 90 degrees sidewalls into which N'-bis(naphthalen-1-yl)-N,N'-bis(phenyl)benzidine (NPB) and tris-(8-hydroxyquinoline) aluminum (Alq3) are thermally evaporated
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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