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Merck

B1636

Sigma-Aldrich

Pentagastrin

≥95% (HPLC), powder, CCK2 receptor agonist

Sinónimos:

Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide

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About This Item

Fórmula empírica (notación de Hill):
C37H49N7O9S
Número de CAS:
Peso molecular:
767.89
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Pentagastrin, ≥95% (HPLC), powder

Ensayo

≥95% (HPLC)

Formulario

powder

condiciones de almacenamiento

(Keep container tightly closed in a dry and well-ventilated place.)

color

white to off-white

solubilidad

DMF: 20 mg/mL, clear, colorless to faint yellow or tan

temp. de almacenamiento

−20°C

cadena SMILES

CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O

InChI

1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)

Clave InChI

NEYNJQRKHLUJRU-UHFFFAOYSA-N

Información sobre el gen

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Amino Acid Sequence

Boc-Bal-Trp-Met-Asp-Phe-NH2

Descripción general

Research area: Immunology & cytokines

Aplicación

Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity.[1] It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[2]

Acciones bioquímicas o fisiológicas

Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin.[3] It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[4] Pentagastrin stimulates the secretion of pepsin and gastric acid.[3] It also aids in the evaluation of gastric acid secretory function.[5] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[4]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Visite la Librería de documentos

Makoto Inada et al.
Scandinavian journal of gastroenterology, 47(2), 148-154 (2012-01-05)
A traditional measurement of gastric acid, involving nasogastric intubation of stomach and acid suction, has been suggested as a gold standard. However, this causes the patient discomfort and cost increase, and is 'time-consuming'. A calcium [(13)C]carbonate (Ca(13)CO(3)) breath test was
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement
Erlich J C, et al.
Frontiers in Behavioral Neuroscience, 6(2-3), 16-16 (2012)
Consistency of immigrant suicide rates in Austria with country-of-birth suicide rates: A role for genetic risk factors for suicide?
Voracek M, et al.
Psychiatry Research, 170(2-3), 286-289 (2009)
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus
Lee Y, et al.
Testing, 8(1), 203-203 (2017)
K McManus et al.
Journal of affective disorders, 66(2-3), 273-279 (2001-10-02)
Panic disorder (PD) symptomatology has been reported to be altered by hormonal events or treatments which affect estrogen levels. Coryell et al. [Arch. Gen. Psychiatry, 39 (1982) 701-703; Am. J. Psychiatry, 143 (1986) 508-510] have suggested that the increased cardiovascular

Questions

1–4 of 4 Questions  
  1. How can Pentagastrin, Product B1636, solutions be stored?

    1 answer
    1. Pentagastrin is subject to oxidation in solution.  A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. What is the shelf-life of Pentagastrin, Product B1636?

    1 answer
    1. This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.

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  4. What is Pentagastrin, Product B1636, soluble in?

    1 answer
    1. Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.

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