A8727

Antalarmin hydrochloride

≥98% (HPLC), solid, CRF1 antagonist

• Sinónimos: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
• Fórmula empírica (notación de Hill): C₂₄H₃₄N₄·HCl
• Número de CAS: 220953-69-5
• Peso molecular: 415.01
• Número MDL: MFCD05664721
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24724401
• NACRES: NA.77

Propiedades

• Nombre del producto: Antalarmin hydrochloride, ≥98% (HPLC), solid
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• condiciones de almacenamiento: desiccated
• color: off-white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
• InChI: 1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
• Clave InChI: CGDGXEDXEXACKQ-UHFFFAOYSA-N

Descripción

Aplicación

Antalarmin hydrochloride has been used:

• to study its effect on stress-induced tryptophan hydroxylase 2 activity[1]
• to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation[2][3]
• to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression[4]

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Acciones bioquímicas o fisiológicas

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.[5]

Características y beneficios

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)