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Merck

PHR1382

Supelco

Ceftriaxone Sodium

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Ceftriaxone disodium salt hemi(heptahydrate)

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About This Item

Fórmula empírica (notación de Hill):
C18H16N8Na2O7S3 · 3.5H2O
Número de CAS:
Peso molecular:
661.60
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
En este momento no podemos mostrarle ni los precios ni la disponibilidad

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to BP 976
traceable to Ph. Eur. C0691000
traceable to USP 1098184

familia API

ceftriaxone

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O.O.O.O.O.O.O.[Na+].[Na+].CO\N=C(/C(=O)N[C@H]1C2SCC(CSC3=NC(=O)C(=O)N([Na])N3C)=C(N2C1=O)C([O-])=O)c4csc(N)n4.CO\N=C(/C(=O)N[C@H]5C6SCC(CSC7=NC(=O)C(=O)N([Na])N7C)=C(N6C5=O)C([O-])=O)c8csc(N)n8

InChI

1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;;;;;;;/h2*5,9,15H,3-4H2,1-2H3,(H5,19,20,21,23,27,29,31,32);;;;;7*1H2/q;;4*+1;;;;;;;/p-4/b2*24-8-;;;;;;;;;;;/t2*9-,15-;;;;;;;;;;;/m11.........../s1

Clave InChI

PMRZKYOXTPBIQF-MAODNAKNSA-J

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Ceftriaxone Sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][2][3] and serum samples[2][3] by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC3447 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Health hazardExclamation mark

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Validation of an HPLC-UV method for the determination of ceftriaxone sodium residues on stainless steel surface of pharmaceutical manufacturing equipments
Akl MA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 55(2), 247-252 (2011)
Simultaneous Determination of Ceftriaxone Sodium and Non Steroidal Anti?Inflammatory Drugs in Pharmaceutical Formulations and Human Serum by RP?HPLC.
Sultana N, et al.
J. Chin. Chem. Soc., 57(6), 1278-1285 (2010)
Simultaneous determination of ceftriaxone sodium and statin drugs in pharmaceutical formulations and human serum by RP-HPLC.
Sultana N, et al.
Journal of the Chilean Chemical Society, 55(2), 193-198 (2010)
A new multidrug-resistant strain of Neisseria gonorrhoeae in Australia.
Monica M Lahra et al.
The New England journal of medicine, 371(19), 1850-1851 (2014-11-06)
Michael S Northrop et al.
Journal of pediatric hematology/oncology, 37(1), e63-e66 (2014-06-01)
Ceftriaxone is a frequently used empiric antibiotic in children. Acute hemolysis is a rare side effect of ceftriaxone therapy associated with a high mortality rate. A 14-year-old boy suffering from Crohn disease developed bacterial pneumonia that was treated with ceftriaxone.

Questions

1–3 of 3 Questions  
  1. What is the active fraction of Ceftriaxone in Cftriaxone sodium(PHR1382-1G)?

    1 answer
    1. Ceftriaxone sodium contains 3.5 parts water and 2 parts sodium. Therefore, the percentage of the active pharmaceutical ingredient (Ceftriaxone) is approximately 83.5%.

      Helpful?

  2. Guten Tag, wo finde ich die Potenz des Antibiotikums? Und wie viele Gram m ist in einer Packung/Flasche?

    1 answer
    1. Unfortunately, the potency is not determined for this product. The active fraction is approximately 83.5%.

      Helpful?

  3. PHR1382 Supelco Ceftriaxone Sodium Please provide the assay purity by HPLC, measured water content and active fraction of the product

    1 answer
    1. The information requested is lot specific and reported in the Certificate of Analysis. Please see the link below to access the lot of interest:
      https://www.sigmaaldrich.com/search

      Helpful?

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