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Merck

PHR1117

Supelco

2,6-Di-tert-butyl-4-methylphenol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Fórmula lineal:
[(CH3)3C]2C6H2(CH3)OH
Número de CAS:
Peso molecular:
220.35
Beilstein:
1911640
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
Número E:
E321
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. B1215000
traceable to USP 1092708

densidad de vapor

7.6 (vs air)

presión de vapor

<0.01 mmHg ( 20 °C)

familia API

butylated hydroxytoluene

CofA

current certificate can be downloaded

temp. de autoignición

878 °F

técnicas

HPLC: suitable
gas chromatography (GC): suitable

bp

265 °C (lit.)

mp

69-73 °C (lit.)

aplicaciones

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

Clave InChI

NLZUEZXRPGMBCV-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Butylated hydroxytoluene (BHT) is a phenolic antioxidant used as a food additive. It is frequently added to dried cereals, cooking oils and animal foods. BHT is also known to enhance the stability of pharmaceuticals, fat-soluble vitamins and cosmetics .

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB3695 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Environment

Palabra de señalización

Warning

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Aquatic Acute 1 - Aquatic Chronic 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

260.6 °F - open cup

Punto de inflamabilidad (°C)

127 °C - open cup


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Certificados de análisis (COA)

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Visite la Librería de documentos

Reactivity of butylated hydroxytoluene.
Lambert CR, et al.
Free Radical Biology & Medicine, 21(3), 395-400 (1996)
Deliang Guo et al.
Science signaling, 2(101), ra82-ra82 (2009-12-17)
Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma, their clinical relevance is poorly understood. Studies of tumors from patients treated
Metabolism and pulmonary toxicity of butylated hydroxytoluene (BHT).
H Witschi et al.
Pharmacology & therapeutics, 42(1), 89-113 (1989-01-01)
Hiroya Okamoto et al.
Experimental dermatology, 21 Suppl 1, 5-7 (2012-06-01)
Pt nanoparticle is a strong reductant and has been used as an antioxidant in cosmetics and medicine. It was reported to have catalase-like activity, which converts hydrogen peroxide to water and oxygen. However, in this study, freshly prepared Pt nanoparticle
Rio P Juni et al.
JACC. Basic to translational science, 4(5), 575-591 (2019-11-27)
The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients with type 2 diabetes mellitus suggest a direct effect of empagliflozin on the heart. These patients frequently have

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