C0225000

Calcitriol

European Pharmacopoeia (EP) Reference Standard

• Sinónimos: 1α,25-Dihydroxyvitamin D₃, 1α,25-Dihydroxycholecalciferol, Calcitriol
• Fórmula empírica (notación de Hill): C₂₇H₄₄O₃
• Número de CAS: 32222-06-3
• Peso molecular: 416.64
• Beilstein: 7559394
• Número MDL: MFCD00867079
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329774770
• NACRES: NA.24

Propiedades

• origen biológico: sheep wool (grease)
• grado: pharmaceutical primary standard
• Agency: EP
• familia API: calcitriol
• Formulario: solid
• fabricante / nombre comercial: EDQM
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: −20°C
• cadena SMILES: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• Clave InChI: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Información sobre el gen: human ... VDR(7421)

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Calcitriol is a biologically active metabolite of vitamin D, formed via hydroxylation of calcidiol in the kidney.

Aplicación

Calcitriol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Biologically active form of vitamin D₃ in calcium absorption and deposition.

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330,H372
• Consejos de prudencia: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Clasificaciones de peligro: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable