PHR1237

Colecalciferol

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: (+)-Vitamina D₃, 7-deshidrocolesterol activado, Activado, 7-deshidrocolesterol, Calciol
• Fórmula empírica (notación de Hill): C₂₇H₄₄O
• Número de CAS: 67-97-0
• Peso molecular: 384.64
• Beilstein: 2339331
• Número CE: 200-673-2
• Número MDL: MFCD00078131
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823242
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 787; traceable to Ph. Eur. C2100000; traceable to USP 1131009
• familia API: cholecalciferol
• Formulario: solid
• CofA: current certificate can be downloaded
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 83-86 °C (lit.)
• aplicaciones: food and beverages
• Formato: neat
• temp. de almacenamiento: -10 to -25°C
• cadena SMILES: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• Clave InChI: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• Información sobre el gen: human ... VDR(7421)

Descripción

Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.

Aplicación

Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds, serum samples and pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

La Vitamina D actúa a través de un receptor que forma parte de la superfamilia del factor de transcripción dependiente del ligando. Modula la proliferación y diferenciación de las células normales y cancerosas. Tiene efectos contrarios a la proliferación y desarrollo de metástasis en células de cáncer de mama, colon y próstata. Receptores activados de vitamina D en el intestino y los huesos mantienen la absorción de calcio y la homeostasis.

La vitamina D actúa a través de un receptor que modula la proliferación y la diferenciación tanto de las células sanas como de las cancerosas.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330,H372
• Consejos de prudencia: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Clasificaciones de peligro: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable